FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions relates to medicine, namely to oncology, and may be used for cancer treatment. Methods and applications according to invention includes administration of (2R,Z)-2-amino-2-cyclohexyl-N-(5-(1-methyl-1H-pirazole-4-yl)-1-oxo-2,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indole-8-yl)acetamide (compound 1) for treatment of cancer, such as colon cancer, prostate cancer and breast cancer in combination with therapeutically efficient amount of anticancer agent selected from gemcitabine, irinotecan and mitomycin C.
EFFECT: application of inventions makes it possible to increase efficiency of colon cancer, prostate cancer and breast cancer treatment by increasing cytotoxicity of hemcitabine, irinotecan, doxorubicin and mitomycin C under action of compound 1.
33 cl, 5 tbl, 42 ex
| Title |
Year |
Author |
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2016 |
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2016 |
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2003 |
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2015 |
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2012 |
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|
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2011 |
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2012 |
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