PREPARATIONS PROVIDING RNA-INTERFERENCE FOR GST-PI GENE MODULATION Russian patent published in 2020 - IPC A61K31/713 A61K31/52 

FIELD: biotechnology.

SUBSTANCE: described is siRNA for inhibiting expression of GST-π, containing a sense chain and an antisense chain, where the chains form a duplex region, and where the antisense strand is SEQ ID NO: 157, and the sense strand is SEQ ID NO: 131, where the length of each chain is 30 nucleotides or less. Described also is a composition containing said siRNA. Disclosed is a method of treating a disease associated with GST-π expression. Also disclosed is siRNA for inhibiting expression of GST-π, comprising a sense chain and an antisense chain, where the chains form a duplex region, and where the antisense strand is SEQ ID NO: 195, and the sense strand is SEQ ID NO: 183, where length of each chain is 30 nucleotides or less. Disclosed are corresponding pharmaceutical compositions.

EFFECT: invention can be used in methods for preventing or treating a disease, such as a malignant tumor.

65 cl, 14 dwg, 14 tbl, 17 ex