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2 630 303

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(51)

IPC

C07D209/56(2006-01-01)

A61K31/404(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2016146910, 2016-11-30

(24)

Start date

2016-11-30

(22)

Actual filing date

2016-11-30

(45)

Published

2017-09-08

(72)

Inventor

Shchegravina Ekaterina SergeevnaFedorov Aleksej YurevichSvirshchevskaya Elena Viktorovna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Issledovatelskij Nizhegorodskij Gosudarstvennyj Universitet Im. N.I. Lobachevskogo"

DERIVATIVE OF 1'-BROMO-2',3',4'-TRIMETOXYBENZO[5',6':4,5]-(AR, 1S)-1-ACETAMIDO-6,7-DIHYDROCYCLOHEPTA-[3,4-F]-1H-INDOLE AND ITS APPLICATION Russian patent published in 2017 - IPC C07D209/56 A61K31/404 A61P35/00

Abstract RU 2630303 C1

FIELD: chemistry.

SUBSTANCE: invention relates to the derivative of 1'-bromo-2',3',4'-trimethoxybenzo[5',6':4,5]-(aR, 1S)-1-acetamido-6,7-dihydrocyclohepta[3,4-ƒ]-1H-indole and its use as the active component of oncology drugs for the cancer treatment. The derivative of 1'-bromo-2',3',4'-trimethoxybenzo [5',6':4.5]-(aR, 1S)-1-acetamido-6.7-dihydrocyclohepta[3.4-ƒ)-1H-indole is represented by the general formula , in which X is the substituent, X=H, Me; R is the substituent, R=Ph, CH₂OH, CH (CH₃) OH, CH₂CH₂OH, CH₂OAc.

EFFECT: compounds have the high apoptosis-inducing activity and activity in inhibiting the proliferation of the tumour cells.

8 cl, 2 dwg, 1 ex

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RU 2 630 303 C1

Authors

Shchegravina Ekaterina Sergeevna

Fedorov Aleksej Yurevich

Svirshchevskaya Elena Viktorovna

Dates

2017-09-08—Published

2016-11-30—Filed