COMPOUNDS Russian patent published in 2017 - IPC C07D401/14 C07D471/04 C07D487/04 A61K31/437 A61K31/519 A61P7/02 

FIELD: pharmacology.

SUBSTANCE: invention relates to compounds of the general formula

,

where Cyc¹ is imidazolyl or triazolyl; Cyc² is phenyl; Cyc³ is phenyl or 5-10 membered heteroaryl containing 1 heteroatom selected from S and N; R¹ is halogen; s is equal to 0 or 1, R² is hydrogen; R³ is hydrogen, C1-8 alkyl or C1-8 alkyl which is substituted by a group selected from pyridyl or -OC1-8 alkyl; Y is N or C (R⁵); R⁴ is hydrogen or C1-4 alkyl; R⁵ is hydrogen or halogen; or R³ and R⁴ can be taken together to form C2 alkylene; where one carbon of the alkylene chain can be replaced by sulfur; R⁶ is C1-8 alkyl, Cyc¹⁰, halogen or Cyc¹⁰ substituted by halogen or cyano, wherein Cyc¹⁰ is a 5-membered heteroaryl containing 3-4 nitrogen atoms; m is equal to 2, where each R⁶ can be the same or different; R⁷ is halogen, -NH₂, -COOR⁴⁸, -NHC (O) O-C1-8 alkyl, -NHC (O) O-C1-4 alkylene-OC1-8 alkyl; R⁴⁸ is hydrogen or C1-8 alkyl; n is equal to 1 or 2, where n is an integer 2, each R⁷ can be the same or different; and R⁶² is hydrogen, their pharmaceutically acceptable salts or solvates thereof.

EFFECT: compounds are factor XIa inhibitors, so they can be used to prevent or treat thromboembolic diseases.

15 cl, 3 tbl, 927 ex