DIHYDROINDOLYSINONE DERIVATIVE Russian patent published in 2019 - IPC C07D471/04 C07D487/04 A61K31/444 A61K31/519 A61P7/02 A61P43/00 

Abstract RU 2707887 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula (I), where

is:

is:

,

and X is CH or N; or a pharmaceutically acceptable salt thereof. Invention also relates to specific compounds, a pharmaceutical composition and an FXIa inhibitor, based on the compound of formula (I), use of said compounds and a method of preventing and / or treating thromboembolic disease.

EFFECT: technical result is obtaining a novel heterocyclic compound having FXIa inhibition effect.

14 cl, 3 dwg, 4 tbl, 46 ex

или - or

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RU 2 707 887 C2

Authors

Tanaka Motoyuki

Kondo Takasi

Khiruka Yasuo

Nisiyama Tajkhej

Khiramatsu Atsusi

Koda Tomoyuki

Keuyama Se

Dates

2019-12-02Published

2015-12-09Filed