FIELD: organic chemistry.
SUBSTANCE: invention relates to crystalline form C of hydrochloride salt of [5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-pyridin-2-yl]-(6-trifluoromethyl-pyridin-3-ylmethyl)-amine (Compound I), which is characterized by an X-ray powder diffraction pattern comprising peaks (±0.2°) at 7.3, 16.6, 20.9, 23.3 and 28.2 °2θ, determined on a diffractometer using Cu-Kα radiation. Invention also relates to a method of treating or preventing and to use for treating or preventing a disease mediated by protein kinase, selected from c-fms, c-kit, Flt3 or a combination thereof.
EFFECT: obtaining a crystalline form of the compound of formula I, having useful biological properties.
25 cl, 23 dwg, 11 tbl, 4 ex
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Authors
Dates
2020-08-24—Published
2016-05-05—Filed