SOLID FORMS OF THE COMPOUND MODULATING THE KINASES Russian patent published in 2020 - IPC C07D471/04 A61K31/437 A61K31/444 A61P35/00 

Abstract RU 2730506 C2

FIELD: organic chemistry.

SUBSTANCE: invention relates to crystalline form C of hydrochloride salt of [5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-pyridin-2-yl]-(6-trifluoromethyl-pyridin-3-ylmethyl)-amine (Compound I), which is characterized by an X-ray powder diffraction pattern comprising peaks (±0.2°) at 7.3, 16.6, 20.9, 23.3 and 28.2 °2θ, determined on a diffractometer using Cu-Kα radiation. Invention also relates to a method of treating or preventing and to use for treating or preventing a disease mediated by protein kinase, selected from c-fms, c-kit, Flt3 or a combination thereof.

EFFECT: obtaining a crystalline form of the compound of formula I, having useful biological properties.

25 cl, 23 dwg, 11 tbl, 4 ex

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RU 2 730 506 C2

Authors

Ibrakhim Prabkha N.

Vajzor Geri Konrad

Dates

2020-08-24Published

2016-05-05Filed