FIELD: pharmacology.
SUBSTANCE: use of inhibitors of Notch signal transmission ways, selected from the group consisting of 6-(4-tret-butylphenoxy)pyridin-3-amine (I3), or some of its derivatives, for treatment and/or prevention of Notch-dependent cancers, application of a pharmaceutical composition and a kit for the same purpose, application of 6-(4-tert-butylphenoxy) pyridin-3-amine (I3) or some of its derivatives to inhibit Notch signal transmission in cells in vitro, in vivo (option), a method for Notch-dependent cancer treatment and a method for treatment of a disease associated with increased activity of Notch signal transmission ways.
EFFECT: realisation of the declared appointments.
19 cl, 10 dwg, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| PYRIDOPYRIMIDINONE DERIVATIVES AND USE THEREOF AS AROMATIC HYDROCARBON RECEPTOR MODULATORS | 2021 |
|
RU2818954C1 |
| NEW ANTI-INVASIVE COMPOUNDS | 2013 |
|
RU2641650C2 |
| CDK4/6 INHIBITOR | 2017 |
|
RU2747311C2 |
| MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | 2011 |
|
RU2576036C2 |
| DISPIROINDOLINONES BASED ON RHODANINES AS P53-MDM2 INHIBITORS OF PROTEIN-PROTEIN INTERACTION | 2019 |
|
RU2730286C1 |
| NOVEL PYRAZOLE DERIVATIVES | 2022 |
|
RU2816835C1 |
| BICYCLIC AGONISTS OF THE INTERFERON GENE STIMULATOR STING | 2020 |
|
RU2800072C1 |
| CYTOTOXIC PEPTIDES AND ANTIBODY-DRUG CONJUGATES THEREOF | 2012 |
|
RU2586885C2 |
| ARYL- AND HETEROARYL-SUBSTITUTED HETEROCYCLIC DERIVATIVES OF UREA, METHOD FOR INHIBITION OF RAF KINASE ACTIVITY AND PHARMACEUTICAL COMPOSITION | 1998 |
|
RU2265597C2 |
| PROTEIN TYROSINE KINASE ACTIVITY INHIBITORS | 2009 |
|
RU2533827C2 |
