NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR ITS SALT Russian patent published in 2017 - IPC C07D213/74 C07D239/48 C07D239/49 C07D401/12 C07D401/14 C07D403/12 C07D405/12 C07D409/12 A61K31/506 A61K31/5377 A61P35/02 

FIELD: chemistry.

SUBSTANCE: invention relates to compound of the general formula [1]-(1): , where R^2ais a hydrogen atom or a C_1-6alkyl group, which may be substituted by one or more substituents selected from a halogen atom; an amino-group; a C_1-6alkylamino-group, which may be substituted by one or more halogen atoms, di(C_1-6alkyl) amino-group, which may be substituted by one or more hydroxy-group, a C_1-6alkylaminocarbonyl and di(C_1-6alkyl) amino-group, or morpholinyl or piperazinyl group, which may be substituted by one or more substituents selected from hydroxy-group, a C_1-6alkyl group and a hydroxy-C_1-6alkyl group, R^4a is a hydrogen atom or a C_1-6alkyl group, which may be substituted by one or more phenyl groups, R^17a is a hydrogen atom or a C_1-6alkyl group, which may be substituted by one or more substituents selected from a halogen atom, the hydroxyl group, and a C_1-6alkoxygroup, provided that R^17a together with R^4a, the nitrogen atom, to which R^4a is attached, and the carbon atom, to which R^17a is attached, may form a nitrogen-containing divalent azetidinyl, pyrrolidinyl, piperidinyl, or azepanyl group, which may be substituted by one or more substituents selected from the atom of the halogen atom, a hydroxyl group, a C_1-3alkyl group or a C_1-6alkoxy group; R^17b and R^18b are the same or different and are a hydrogen atom or a C_1-6alkyl group, which may be substituted by one or more substituents selected from the atom of the halogen atom, a hydroxyl group and a C_1-6alkoxy group, provided that R^17b and R^18b together with the carbon atom, to which they are attached, can form C(=O), or R^17b and R^18b together with the carbon atom, to which they are attached, may form a tetrahydropyrandyl group; R^9a is a C_1-6alkoxy group, pyrrolidinyl, piperidinyl, piperazinyl, pyrazolidine, triazoline, or morpholinyl group, which may be substituted by one or more substituents selected from the atom of the halogen atom and a C_1-3alkyl group, or N(R¹⁵)(R¹⁶), where R¹⁵ is a hydrogen atom or a C_1-6alkyl group, and R¹⁶ is a C_1-6alkyl group, which may be substituted by one or more groups selected from a halogen atom, a cyano group, a C_3-6cycloalkyl group, a phenyl group, which may be substituted by one or more halogen atoms, a C_1-6alkoxy group, di(C_1-6alkyl) amino-group, and a morpholinyl, a tetrahydropyranyl, or a thiophenol group, a C_3-8cycloalkyl group, a phenyl group, which may be substituted by one or more groups selected from a halogen atom, a cyano group, a C_1-6alkyl group, a C_1-6alkoxy group, or a pyridinyl or chinolyl group, which may be substituted by one or more C_1-6alkoxy group, or R¹⁵ and R¹⁶ may form a cyclic amino-group, which may be substituted by one or more groups selected from halogen and a C_1-3alkyl group, and R^12a is a C_1-6alkyl group, which may be substituted by one or more groups selected from the hydroxy groups, di(C_1-6alkyl) amino-group or a pyridinyl, a morpholinyl, or a pyrrolidinyl group, a phenyl group, which may be substituted by one or more groups selected from the halogen atom; a cyano group; an amino-group, which may be protected by the acyl group; a carbamoyl group, which may be substituted by one or more groups selected from the C_1-6alkyl groups and the C_3-8cycloalkyl group; a C_1-6alkyl group, which may be substituted by one or more groups selected from halogen and the triazoline group; a C_1-6alkoxy group, which may be substituted with halogen; or pyrazolidine, triazoline, or thiazolidine group which may be substituted by one or more groups selected from C_1-6alkyl group and ceanography, or pyridyloxy, izohinolinove, talinolol, isoxazolidine, isothiazolinone, thiadiazolidine, indazolinone, benzothiazolyl, chinolyl, benzoxazolyl, or pyrazolopyrimidinyl group, which may be substituted by one or more groups selected from halogen, a C_1-6alkyl group, which may be substituted by one or more C_1-6alkoxy group, a C_1-6alkoxy group, a C_1-6alkyl amino-group, a C_1-6alkoxy carbonyl group, or a morpholinyl group; X^2a is a C_1-6alkylene group, which may be substituted by one or more substituents selected from exography and the C_1-6alkyl group, a divalent C_2-6alicyclic hydrocarbon group, or a divalent aromatic hydrocarbon group, which may be substituted by one or more groups selected from halogen, a C_1-6alkyl group, which may be substituted by halogen and the C_1-6alkoxy group, and X^3a is a C_2-6alkynyl amino-group, or N(R²²)-C(=O), where R²² is a hydrogen atom.

EFFECT: compounds are an inhibitor of Fms-like tyrosine kinase 3, which can be used as a therapeutic agent for acute myelogenous leukemia.

21 cl, 261 tbl, 70 ex