PYRIMIDYL-DI(DIAZADISPIROALKANE)S WITH ANTIVIRAL ACTIVITY Russian patent published in 2017 - IPC C07D487/20 A61P31/12 

FIELD: pharmacology.

SUBSTANCE: compounds have a broad spectrum of antiviral activity and can be used for treatment and/or prevention of diseases caused by papillomavirus infection, infection caused by the immunodeficiency virus, cytomegalovirus or hepatitis B or C virus. In general formula I , X = CH₂, Y = CH₂CH₂ or X = CH₂CH₂, Y = CH₂; A is pyrimidine-4,6-diyl or pyrimidine-2,4-diyl, which may contain, as substituents, H, NO₂, CHO, OH, OAlk, a halogen atom, NH(Alk), N(Alk) 2 group; wherein Alk is a linear or branched substituent having from 1 to 4 carbon atoms; Hal is a halogen atom, or X = Y = CH₂; A is pyrimidin-4,6-diyl or pyrimidine-2,4-diyl, which has Cl, Br, CH₃, HE atom as its substituent;Hal is a halogen, chlorine or bromine atom. Preference is given to compounds of formula (I) where X = CH₂CH₂, Y = CH₂ or X = CH₂, Y = CH₂CH₂, A = pyrimidine-4,6-diyl, which may have H, NO₂, Alk group, as substituents; Hal = chlorine or bromine and Alk = methyl.

EFFECT: increased composition application effeciency.

11 cl, 2 dwg, 2 tbl, 13 ex