FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing substituted pyrimidin-5-yl carboxylic acids of formula I 
and can be used in organic chemistry. The method is realised by reacting N-substituted guanidines and hetarylamidines with ethoxymethylene derivatives of 1,3-ketoesters according to a scheme given below (where the substitutes are as defined in the claim).
EFFECT: improved method of producing substituted pyrimidin-5-yl carboxylic acids of formula I.
2 tbl, 14 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTITUTED 4-(SELENOPHEN-2(OR 3)-YLAMINO) PYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | 2011 |
|
RU2597609C2 |
| PYRAZOLE DERIVATIVES APPLIED AS PROTEIN KINASE INHIBITORS | 2013 |
|
RU2623221C2 |
| 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEINKINASE INHIBITORS | 2005 |
|
RU2379308C2 |
| SUBSTITUTED 2H-PYRANO[2,3-C]PYRIDINES, COMBINATORY AND FOCUSED LIBRARIES | 2003 |
|
RU2261251C2 |
| (1,2,3-TRIAZOLYL)-1,2,3-OXADIAZOLE DERIVATIVES POTENTIATING NO-DEPENDENT ACTIVATION OF SOLUBLE FORM OF GUANYLATE CYCLAZE | 2000 |
|
RU2158265C1 |
| THROMBIN INHIBITORS AND INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS | 1995 |
|
RU2172741C2 |
| SUBSTITUTED 4-(ARYLAMINO) SELENOPHENOPYRIMIDINE COMPOUNDS AND METHODS OF THEREOF APPLICATION | 2011 |
|
RU2566293C2 |
| PYRIMIDINE DERIVATIVES USED AS PROTEIN KINASE INHIBITORS | 2008 |
|
RU2478100C2 |
| BIS-AMMONIUM COMPOUNDS BASED ON PYRIDOXINE, HAVING ANTIBACTERIAL AND ANTIMYCOTIC PROPERTIES | 2020 |
|
RU2731999C1 |
| QUINAZOLINE COMPOUNDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND PHARMACEUTICAL COMPOSITION | 1993 |
|
RU2135481C1 |
