NEW SOLID FORMS OF TYPE 5 PHOSPHODIESTERASE INHIBITORS Russian patent published in 2017 - IPC C07D471/14 A61K31/50 A61P9/14 

FIELD: pharmacology.

SUBSTANCE: invention relates to new solid forms of type 5 phosphodiesterase inhibitors (PDE-5), namely to crystalline compounds consisting of a tadalafil of formula T

and coformer Y in which Y is selected from 3-hydroxybenzoic acid, 2,3-dihydroxybenzoic acid, 2,5-dihydroxybenzoic acid, 3,4,5-trihydroxybenzoic acid, D-malic acid and L-tartaric acid, especially to complex cocrystals and their solvates, as well as to pharmaceutical compositions containing the above compounds as a useful active ingredient.

EFFECT: high permanent storage stability.

14 cl, 20 dwg