COMPOSITIONS AND METHODS FOR TREATMENT OF CHRONIC INFLAMMATION AND INFLAMMATORY DISEASES Russian patent published in 2017 - IPC A61K9/08 A61K31/192 A61K47/10 A61K47/44 A61P29/00 

FIELD: pharmacology.

SUBSTANCE: group of inventions refers to an oral pharmaceutical composition with anti-inflammatory activity, to a method for preparation of the said composition, to application of an oral pharmaceutical composition for manufacture of a medicament for treatment of chronic inflammation, to application of an oral pharmaceutical composition for treatment of chronic inflammation, and to a method for treatment of an individual with chronic inflammation. The pharmaceutical composition comprises: a) a non-steroidal anti-inflammatory drug (NSAID), which is a propionic acid derivative that has a log P value greater than 2.0; b) 0.01-15 vol. % of a pharmaceutically acceptable solvent, wherein the solvent is a pharmaceutically acceptable liquid polyethylene glycol polymer; and c) at least 50 vol. % of a pharmaceutically acceptable hydrophobic lipid adjuvant, wherein the pharmaceutically acceptable hydrophobic lipid adjuvant consists of a fatty acid triglyceride, a fatty acid diglyceride and a fatty acid monoglyceride, wherein the pharmaceutical composition is prepared so as to be in a solid state at a temperature of 15°C or lower and has a melting point of 25°C or higher.

EFFECT: group of inventions allows the delivery of a therapeutic chemical compound with anti-inflammatory activity so that it more effectively inhibits the anti-inflammatory response, which ultimately increases the effectiveness of chronic inflammation treatment.

16 cl, 4 dwg, 7 tbl, 10 ex