FIELD: medicine.
SUBSTANCE: methylation of the promoter regions of MGMT, CDH1, p16/CDKN2A, DAPK, RAR-β and RUNX3 genes in the esophagus mucosa samples obtained during biopsy in endoscopic study is determined by methyl sensitive PCR. If abnormal methylation of at least one of these genes is detected, a conclusion is made that the risk of oncological progression is increased by a factor of 10.
EFFECT: increased accuracy in the diagnosis of the risk of malignant epithelium of the esophagus.
1 dwg, 1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| EARLY DNA-DIAGNOSTIC TECHNIQUE OF PROSTATE CANCER | 2009 |
|
RU2405837C1 |
| METHOD FOR FORMATION OF DNA METHYLATION MARKER SYSTEMS | 2011 |
|
RU2472859C1 |
| METHOD FOR PREDICTION OF CERVICAL CANCER IN BENIGN AND PRE-CANCER CERVICAL PROCESSES IN FEMALES OF REPRODUCTIVE AGE | 2011 |
|
RU2466392C2 |
| METHOD OF PERSONALIZATION OF MEDICAL CARE FOR PATIENTS WITH STOMACH CANCER | 2019 |
|
RU2713907C1 |
| METHOD OF DETERMINING HYPERMETHYLATED CpG ISLANDS IN REGION OF SUPPRESSOR GENES OF TUMOUR GROWTH IN HUMAN DNA | 2009 |
|
RU2413773C1 |
| METHOD FOR ANALYSING DIFFERENTIALLY METHYLATED GENOMIC REGIONS IN BIOLOGICAL SAMPLES OF BONE MARROW AND BLOOD OF CHILDREN WITH ACUTE MYELOID LEUKAEMIA | 2017 |
|
RU2689727C2 |
| METHOD FOR PREDICTING THE CLINICAL COURSE OF NEUROENDOCRINE NEOPLASMS OF THE COLON | 2021 |
|
RU2771421C1 |
| METHOD TO PRODUCE RECOMBINANT ANTI-ANGIOGENIC POLYPEPTIDE | 2012 |
|
RU2488635C1 |
| METHOD FOR PREPARATION OF GENOMIC LIBRARIES OF LIMITED SELECTIONS OF LOCUSES FROM DEGRADED DNA | 2015 |
|
RU2625012C2 |
| METHOD FOR PREDICTION OF DEVELOPING ENDOMETRIAL CANCER IN PATHOLOGICAL ENDOMETRIAL PROCESSES IN FEMALES OF REPRODUCTIVE AGE | 2011 |
|
RU2466390C2 |
