FIELD: biotechnology.
SUBSTANCE: invention relates to development of outer surface protein A (OspA) chimeric molecules, and can be used in medicine. The designed chimeric polypeptide with SEQ ID NO: 173, as well as compositions and combined vaccines that contain it, are able to elicit a specific immune response against bacteria of Borrelia genus.
EFFECT: invention can effectively treat and prevent Borrelia infections or Lyme disease.
36 cl, 24 dwg, 9 tbl, 22 ex
| Title |
Year |
Author |
Number |
| CHIMERIC OSPA GENES, PROTEINS AND THEIR APPLICATION METHODS |
2011 |
- Krou, Brajan, A.
- Livi, Ian
- O'Rurk, Mariya
- Shvendinger, Mikhel
- Laft, Benzhamin Dzh.
- Dann, Dzhon Dzh.
|
RU2773402C2 |
| OSPA CHIMERIC GENES, PROTEINS AND METHODS FOR USE THEREOF |
2011 |
- Krou Brajan A.
- Livi Ian
- O'Rurk Marija
- Shvendinger Mikhel
- Dann Dzhon Dzh.
- Laft Bendzhamin Dzh.
|
RU2583289C2 |
| RECOMBINANT CHIMERIC POLYPEPTIDES, CARRYING EPITOPES OF VARIOUS IMMUNODOMINANT PROTEINS OF SPIROCHAETA OF BORRELIA BURGDORFERI SENSU LATO COMPLEX, AND SERUM DIAGNOSTIC TECHNIQUE FOR IXODIC TICK-BORNE BORRELIOSIS |
2012 |
- Beklemishev Anatolij Borisovich
- Rjabchenko Aleksandr Vladimirovich
- Karavaev Vitalij Semenovich
|
RU2514230C1 |
| VACCINE AGAINST LYME DISEASE IN DOGS |
2018 |
- Lafleur, Rhonda, L
- Dant, Jennifer, C
- Mogler, Mark, A
- Callister, Steven, M
- Xu, Zhichang
|
RU2785620C2 |
| DNA ANTIBODY CONSTRUCTIONS FOR USE AGAINST LYME DISEASE |
2017 |
- Weiner, David, B.
- Flingai, Seleeke
|
RU2813829C2 |
| IMMUNOGENIC COMPOSITIONS FOR IMMUNIZATION OF PIGS AGAINST CIRCOVIRUS TYPE 3 AND METHODS OF PRDUCTION AND APPLICATION THEREOF |
2016 |
|
RU2744193C2 |
| VACCINES AND VACCINE INGREDIENTS FOR MICROBIAL CELL INHIBITION |
2008 |
- Al'Termann Ehrikh Khajnts
- Ehttvud Grehm Trevor
- Li Dun
- Kelli Vill'Jam Dzhon
- Kun Chzhankhao
- Likhi Shinejd Kristin
|
RU2528854C2 |
| BORRELIA HYBRID PROTEIN, NUCLEIC ACID CODING THIS PROTEIN, EXPRESSING CARTRIDGE, VECTOR, METHOD AND KIT FOR DIAGNOSING LYME BORRELIOSIS, VACCINE FOR BORRELIOSIS PREVENTION |
2010 |
- Leve, Lionel'
- Mezhan-Leturner, Odil'
|
RU2549698C2 |
| IMMUNOGENIC COMPOSITIONS FOR IMMUNISING PIGS AGAINST TYPE 3 CIRCOVIRUS AND METHODS FOR PRODUCTION AND APPLICATION THEREOF |
2016 |
|
RU2771533C2 |
| IMMUNOGENIC COMPOSITIONS FOR IMMUNIZATION OF PIGS AGAINST TYPE 3 CIRCOVIRUS AND METHODS OF THEIR PRODUCTION AND USE |
2022 |
|
RU2803427C1 |
