CHIMERIC OSPA GENES, PROTEINS AND THEIR APPLICATION METHODS Russian patent published in 2022 - IPC C07K14/20 A61K39/02 A61P31/00 A61P31/04 A61P31/14 A61P33/00 A61P33/14 A61P37/04 A61P43/00 

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, in particular to immunogenic compositions capable of causing a specific immune response against Borrelia bacteria; it can be used in medicine. More specifically, the invention relates to new chimeric OspA molecules containing a proximal section of one OspA serotype together with a distal section of another OspA serotype, while saving antigenic properties of both parent polypeptides, as well as to nucleic acids encoding them.

EFFECT: pharmaceutical compositions containing the specified nucleic acids as an active ingredient can be used as a drug in the gene therapy of borreliosis, Lyme disease and other tick-borne diseases.

12 cl, 22 ex, 9 tbl, 24 dwg