FIELD: medicine.
SUBSTANCE: there are presented recombinant chimeric polypeptides rmBmpA-frp83, rmOspA-frp83, rmDbpB-rmOspA, rmFlaA-frFlaB and rmOspCBg-rmOspCBa, prepared on the basis of gene expression amplified by PCR on the DNA of Borrelia garinii 20047T Western-Siberian isolate or in case of the protein rmOspCBa, on the DNA of Borrelia afzelii isolate.
EFFECT: invention extends the range of recombinant polypeptides applicable for the serum diagnosis of ixodic tick-borne borreliosis, providing higher specificity and sensitivity of the ITBB, including the differential diagnosis of the early stage and the stage of a disseminated infection in the territories of Borrelia burgdorferi s1 Western-Siberian isolates.
8 cl, 2 dwg, 3 tbl, 5 ex
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