METHODS AND APPLICATIONS OF INHIBITORS OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN, TYPE 9 (PCSK9) Russian patent published in 2017 - IPC A61K39/395 A61K31/4745 A61K31/7088 A61K38/17 A61P29/00

Abstract RU 2636820 C2

FIELD: medicine.

SUBSTANCE: proprotein convertase subtilisin/kexin 9 (PCSK9) is administered to a subject in need thereof, wherein the PCSK9 inhibitor is an antibody or an antigen-binding fragment thereof. Also, PCSK9 application is proposed for manufacture of a medicament for sepsis or septic shockr treatment. A pharmaceutical composition and a commercial package containing the PCSK9 inhibitor.

EFFECT: possibility of treatment of a patient with sepsis or septic shock at doses suitable for intensive care.

21 cl, 5 dwg, 7 tbl

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RU 2 636 820 C2

Authors

Uollej Kit R.

Bojd Dzhon Kh.

Rassel Dzhejms A.

Dates

2017-11-28—Published

2013-05-17—Filed