FIELD: medicine.
SUBSTANCE: invention relates to a method for determination of the total volume of therapeutic multispecific antibody in a serum or plasma sample using a sandwich-type immunoassay, encompassing a stage of determination of the amount of complex formed between I) an anti-idiotypic antibody which specifically binds to the first binding specificity of the therapeutic multispecific antibody and II) therapeutic multispecific antibody by complex incubation with the anti-idiotypic antibody which specifically binds to the second binding specificity of therapeutic multispecific antibody, different from the first binding specificity, and thus the volume of therapeutic multispecific antibody is determined in the sample.
EFFECT: improved immunoassay for determination of the multispecific antibody volume in a sample.
2 cl, 4 dwg, 5 tbl, 3 ex
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