METHOD FOR SELECTION AND PRODUCTION OF SELECTIVE AND MULTISPECIFIC THERAPEUTIC MOLECULES WITH SPECIFIED PROPERTIES, INCLUDING, AT LEAST TWO, DIFFERENT TARGET GROUPS, AND THEIR APPLICATIONS Russian patent published in 2018 - IPC C07K16/00 C07K16/46 A61K39/395 A61P35/00 

FIELD: biotechnology.

SUBSTANCE: methods include the next step: identification of binding specificity and/or affinity of many bispecific antibodies obtained by combining each element of the first plurality of antibody Fab-fragments or antibody scFv-fragments with each element of the second plurality of antibody Fab fragments or antibody scFv-fragments and with a linker, containing the second element of the first binding pair on its one end and the second element of the binding pair on its corresponding other end.

EFFECT: invention allows you to efficiently receive multispecific therapeutic molecules, such as bispecific antibodies, with the specified properties with regard to cell surface molecules on the cell of the patient, who is in need of treatment, or with regard to ligands, interacting with such cell surface molecule.

11 cl, 28 dwg, 8 tbl, 13 ex