METHOD FOR PREVENTION OF EARLY POSTOPERATIVE COGNITIVE DYSFUNCTION IN PATIENTS WITH DIGESTIVE ORGANS PATHOLOGY Russian patent published in 2017 - IPC A61K31/415 A61K31/02 A61P25/20 

FIELD: medicine.

SUBSTANCE: preliminary study of the cognitive and psychological status of the patient is performed. Combined anaesthesia is performed, including inhalation endotracheal sevoflurane anaesthesia and prolonged epidural analgesia. In this case, when a patient is diagnosed with initial cognitive impairment, chronic pain syndrome, anxiety and depression, a potentized anaesthetic with sevoflurane at a dose of 1.8-2.0% in oxygen is performed in the preoperative period. Immediately after trachea intubation, micro-jet infusion of dexmedetomidine is added at a dose of 0.4-0.8 mcg/kg/h, which is continued until suturing of the postoperative wound begins. The bispectral index of the electroencephalogram during the operation is maintained in the range of 40-60%.

EFFECT: method allows to increase the effectiveness of prevention of early POCD development in patient subject to surgery due to GIT cancer, to reduce the opioids dose, to exclude the risk of application of excessively high doses of anaesthesia drugs.

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