METHOD FOR PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING Russian patent published in 2024 - IPC A61K31/417 A61K33/00 A61K31/04 A61K31/573 A61P1/08 

FIELD: medicine.

SUBSTANCE: invention refers to anaesthesiology and intensive care and concerns a method for prevention of postoperative nausea and vomiting. To maintain anaesthesia, a combination of preparations is used: xenon inhalation at a gas flow of 2 l/min with FiO₂=30% until its concentration in the inhaled gas mixture is 50–55% and subsequent maintenance of said concentration in a closed breathing circuit at a gas flow of 150–200 ml/min with FiO₂ of not less than 35%. Intravenous administration of dexmedetomidine in regimen of 0.5 mcg/kg/h is carried out immediately after induction of anaesthesia and is stopped 20 minutes before completion of the operation; nefopam diluted in physiological saline 20 ml in regimen of 0.2 mg/kg/h 1 hour before the end of the operation, as well as a single bolus intravenous introduction of dexamethasone in dose of 0.1 mg/kg 1 hour before the end of the operation.

EFFECT: invention provides prevention of postoperative nausea and vomiting in the intraoperative period during anaesthetic management.

1 cl, 2 ex