FIELD: biotechnology.
SUBSTANCE: invention relates to production of a photosensitive chimeric protein capable of incorporating a light signal into the signalling cascade of metabotropic glutamate receptor 6 (mGluR6), which is a natural component of the ON-bipolar cell membrane in the inner layer of the retina, which can be used in medicine. A GPCR chimeric protein is obtained comprising domains of at least two members of a protein receptor superfamily conjugated with G proteins (GPCR), a nucleic acid encoding the said protein, an expression vector comprising the said nucleic acid, as well as a transgenic cell line containing genetic information, encoding a chimeric GPCR protein.
EFFECT: invention allows effective drug therapy and production of an effective drug for vision improvement, in particular, for treatment of vision loss due to degeneration of retinal photoreceptors.
32 cl, 6 dwg, 1 tbl, 1 ex
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| USING VECTOR FOR REDUCING IMMUNE RESPONSE IN VIRAL DELIVERY OF AIPL1 | 2023 |
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| CONDITIONALLY ACTIVE CHIMERIC ANTIGENIC RECEPTORS FOR MODIFIED T CELLS | 2016 |
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RU2759957C2 |
