FIELD: esthetic medicine.
SUBSTANCE: group of inventions relates to a skin filler composition for treatment of wrinkles on the skin, containing hyaluronic acid cross-linked with a diamine crosslinker selected from lysine or a lysine methyl ester and a carbodiimide binder; to a method for preparation of the said composition, according to which cross-linking of hyaluronic acid with a diamine cross-linker selected from lysine or a lysine methyl ester is carried out in the presence of a carbodiimide binder; as well as a method of treatment of fine lines on the skin, comprising composition administration to the dermal region of a patient.
EFFECT: group of inventions provides an injectable skin filler composition that does not lead to blueing after introduction into the skin region of the patient, is not cytotoxic, has good mechanical properties and improved biocompatibility.
11 cl, 18 ex, 6 tbl, 2 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITION OF SKIN FILLER AND TREATMENT METHOD | 2012 |
|
RU2679317C1 |
| DERMAL FILLER COMPOSITION FOR SMALL WRINKLES TREATING | 2012 |
|
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| HYALURONIC ACID-BASED COACERVATE HYDROGELS FOR USE IN DERMAL FILLERS | 2016 |
|
RU2750684C2 |
| DERMAL FILLERS COMPOSITIONS, INCLUDING ANTIOXIDANTS | 2012 |
|
RU2624239C2 |
| DERMAL FILLER COMPOSITIONS, INCLUDING ANTIOXIDANTS | 2012 |
|
RU2740454C2 |
| HYDROGEL CONTAINING HYALURONIC ACID DERIVATIVE MODIFIED WITH GALLOL GROUP AS SUBSTRATE, AND ITS USE | 2018 |
|
RU2778054C2 |
| CROSS-LINKED POLYSACCHARIDE COMPOSITIONS IN SITU AND VERSIONS OF THEIR USE | 2016 |
|
RU2734419C2 |
| GEL OF HYALURONIC ACID FOR INTRACUTANEOUS INJECTION | 2007 |
|
RU2448740C2 |
| MODIFIED HYALURONIC ACID, METHOD FOR PRODUCTION THEREOF AND USE THEREOF | 2017 |
|
RU2733444C2 |
| STABILIZED HYALURONIC ACID | 2019 |
|
RU2805502C2 |
