FIELD: chemistry.
SUBSTANCE: group of inventions relates to a high-molecular weight glycosaminoglycan hydrogel. Method of producing hydrogel involves cross-linking glycosaminoglycan (GAG), having a molecular weight of 2.1–3.5 MDa, a cross-linking agent to obtain a glycosaminoglycan hydrogel cross-linked by amide bonds, where the cross-linking agent is a di- or polynucleophilic functional cross-linking agent containing a spacer group selected from di-, tri-, tetra- and oligosaccharides; wherein concentration of GAG is from 2% to 10 (wt./wt.)%, molar ratio of cross-linking agent to GAG is less than or equal to 2 mol.% on disaccharide GAG. Also disclosed is a hydrogel product and a method for restoring, reconstructing or growing hard or soft tissue.
EFFECT: group of inventions provides resistance to gel degradation.
19 cl, 5 dwg, 3 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| INJECTION GEL PRODUCT | 2018 |
|
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| METHOD FOR DEACETYLATION OF BIOPOLYMERS | 2016 |
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| COMPOSITION OF SKIN FILLER AND TREATMENT METHOD | 2012 |
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| CARBOHYDRATE CROSS-LINKING AGENT | 2016 |
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| SKIN FILLERS COMPOSITIONS | 2012 |
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| STABILIZED HYALURONIC ACID | 2019 |
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RU2805502C2 |
| METHOD FOR MANUFACTURING FORMATED PRODUCT FROM CROSS-LINKED HYALURONIC ACID | 2013 |
|
RU2640865C2 |
| DERMAL FILLER COMPOSITION FOR SMALL WRINKLES TREATING | 2012 |
|
RU2626513C2 |
| GEL OF HYALURONIC ACID FOR INTRACUTANEOUS INJECTION | 2007 |
|
RU2448740C2 |
