FIELD: chemistry.
SUBSTANCE: invention relates to the method for obtaining aromatic acetylene ketones of the common formula
,
where Ar, Ar' - aromatic radicals, which find a wide variety of applications in the synthesis of various heterocyclic compounds. The method comprises reacting an acetylene component with aldehyde in the presence of Lewis acid in an organic solvent. Tin tetraalkynides are used as an acetylene component in toluene at a temperature of 40-60°C for 4-6 hours using zinc chloride as a Lewis acid according to the scheme:
.
2 equivalents of aldehyde are spent for 1 equivalent of the acetylene fragment.
EFFECT: method allows to obtain target products using a simple technology.
1 tbl, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR OBTAINING ACETYLENE KETONES | 2017 |
|
RU2641697C1 |
| METHOD OF PRODUCING SILYLOXYAMINES | 2019 |
|
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| METHOD FOR PRODUCING 1H-BENZO[F]CHROMEN-2-YL(ARYL)KETONES | 2015 |
|
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| METHOD OF PRODUCING 2,4-DISUBSTITUTED FURANS | 2023 |
|
RU2810211C1 |
| PROCESS FOR PREPARATION OF 1-(1H-BENZOCHROMEN-2-YL)-2,2,2-TRIFLUOROETHANONES | 2016 |
|
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| CONVERTING ALCOHOLS INTO LINEAR AND BRANCHED FUNCTIONALISED ALKANES | 2017 |
|
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| METHODS OF SYNTHESIS OF ESTEINASCIDINE, COMPOUNDS, INTERMEDIATE SUBSTANCE | 1997 |
|
RU2194709C2 |
| USE OF N-[1-ARYL-3-OXO-2-AZASPIRO[3.5]NONAN-2-YL]BENZAMIDES AS ANALGESIC MEDICINAL PRODUCTS | 2023 |
|
RU2810704C1 |
| PYRAZOLE COMPOUNDS AS SIGMA RECEPTOR INHIBITORS | 2011 |
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RU2582338C2 |
| PRODRUG FORMING COMPOUNDS | 2014 |
|
RU2667942C2 |
