HETERO-AROMATIC METHYLIC DERIVATIVE OF CYCLIC AMINE Russian patent published in 2017 - IPC C07D413/14 A61K31/4439 A61K31/5355 A61K31/422 A61P1/04 A61P1/14 A61P3/00 A61P9/12 A61P25/06 A61P25/08 A61P25/14 A61P25/16 A61P25/18 A61P25/20 A61P25/22 A61P25/24 A61P25/28 A61P25/36 A61P29/00 A61P37/02 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound represented by the formula (IA), where X¹ and X² are the same or different and are a nitrogen atom or a CH group; Y is any structure from the following group of formulas (a); n is 1 or 2; R¹ is a hydrogen atom, a halogen atom or a C_1-6 alkyl group; R² is a triazolyl group or a pyrimidinyl group; R³ is a hydrogen atom or a halogen atom; and R⁴ is a hydrogen atom or a C_1-6 an alkyl group; or a pharmaceutically acceptable salt thereof. The invention also relates to a compound represented by the formula (I), where X¹ and X² are the same or different and are a nitrogen atom or a CH group; any one of Y¹ and Y² is a nitrogen atom, and the other is CH; n is 1 or 2; R¹ is a hydrogen atom, a halogen atom or a C_1-6 alkyl group;R² is a triazolyl group or a pyrimidinyl group; R³ is a hydrogen atom or a halogen atom; and R⁴ is a hydrogen atom or a C_1-6 alkyl group; or a pharmaceutically acceptable salt thereof. The compounds of the invention are intended for the production of a pharmaceutical composition having antagonistic activity against OX1 and OX2 orexin receptors.

EFFECT: hetero-aromatic methyl derivative of cyclic amine, which has antagonistic activity against OX1 and OX2 orexin receptors.

9 cl, 6 tbl, 85 ex