INHIBITOR OF ATP-DEPENDENT REVERSE CELL TRANSPORTERS AND METHOD FOR ITS PRODUCTION Russian patent published in 2018 - IPC C07C43/11 A61K31/08 C07C41/03 

FIELD: biotechnology.

SUBSTANCE: invention relates to an inhibitor of ATP-dependent reverse cell transporters belonging to a group of chiral conjugates (optically active hybrid molecules) of an oligoether polyol nature, as well as to a method for its production. The inhibitor is a mixture of polyoxypropylenehexole of formula 4

,

where n=2-6, and polyoxypropylene glycol of formula 5

,

where m=5-9, and has a hydroxyl number of 215-240 mg KOH/g. Compound 4 has a molecular weight of 1000 to 1500 Da, compound 5 has a molecular weight of 300 to 500 Da, and the mole ratio of compounds 4 and 5 is 0.9-1.1. The method for inhibitor production is to prepare a mixture of sorbitol ((2S, 3R, 4R, 5R)-hexane-1,2,3,4,5,6-hexol) and bifunctional oxygenate compound H-R-H, where R=-O-; [-OCH₂CH (CH₃)]_k-O-, and k=1-7, in the presence of an alkali or alkaline earth metal hydroxide, with further interaction of this mixture with propylene oxide, neutralisation of the product obtained with acid and subsequent purification of the product.

EFFECT: increased yield.

3 cl, 9 dwg, 4 tbl, 16 ex