TRIFUNCTIONAL ETHYLENE OXIDE AND PROPYLENE OXIDE BLOCK COPOLYMERS FOR ACTIVE SUBSTANCE DELIVERY TO LIVING CELLS Russian patent published in 2013 - IPC A61K47/34 A61K31/704 

Abstract RU 2501570 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry, and represents a polymer carrier for an increase of the accumulation of biologically active substances in living cells, differing by the fact that it represents a compound of formula A or B:

with the number of monomer ethylene oxide units x=1÷10 and propylene oxide units y=1÷30.

EFFECT: invention provides reducing the cytotoxicity of the polymer carriers of the biologically active substances ensured by using the safer compounds of formula A or B; higher efficacy of the intracellular transport of the biologically active substances, increasing the toxicity of anti-cancer antibiotics in relation to resistant cancer cells ensured by more effective inhibition of the membrane transporters by the compounds of formula A or B.

4 cl, 4 ex, 2 tbl, 1 dwg

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RU 2 501 570 C1

Authors

Shtyrlin Jurij Grigor'Evich

Abdullin Timur Ildarovich

Bondar' Oksana Viktorovna

Sagitova Alsu Vakifovna

Badeev Jurij Vladimirovich

Dates

2013-12-20Published

2012-05-11Filed