FIELD: medicine.
SUBSTANCE: invention relates to experimental toxicology, and can be used to study the mechanisms of the toxic effect of beryllium soluble forms. To do this, simulation of intoxication with beryllium salts is carried out by single or prolonged repeated intraperitoneal injection of beryllium salts. Salts are introduced as a solution in 0.2 M glycine buffer at pH 9.2. This allows administration of up to 90 mg/kg animal body weight in terms of beryllium ion. The method reproduces poisoning in the absence of the effect of a sudden change in the concentration of beryllium ions and violation of acid-base equilibrium.
EFFECT: extremely high toxic load on the body while preserving the life of the laboratory animal.
3 ex, 4 tbl
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