COMPOSITIONS, SYNTHESIS AND METHODS FOR APPLICATION OF PHENYLCYCLOALKYLMETHYLAMINE DERIVATIVES Russian patent published in 2018 - IPC C07C211/26 C07C211/25 A61K31/13 A61P3/04 A61P25/24 

FIELD: pharmacology.

SUBSTANCE: invention relates to new phenylcycloalkylmethylamine derivatives of structural formula (I), or enantiomers or optically active isomers, or pharmaceutically acceptable salts having affinity for the binding of dopamine (DAT), the carrier of norepinephrine (NET) and the serotonin transporter (SERT). The compounds may find use in treatment and/or prevention of obesity, as well as depression 1. In the structural formula (I)

,

n is 1; SP is a spacer, wherein the said spacer is C₄ alkylene; X is O or S; R¹ and R² are independently H, C_1-6 alkyl, C_1-6 alkoxy, halogen; R³ is C_1-6 alkyl; R⁴ is H or C_1-6 alkyl; R⁵ is C_1-6 alkyl; and * represents a carbon atom that can be optically active.

EFFECT: improved composition properties.

12 cl, 1 tbl, 86 ex