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2 642 420

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IPC

C07D487/04(2006-01-01)

(21) (22)

Application

2017114083, 2017-04-21

(24)

Start date

2017-04-21

(22)

Actual filing date

2017-04-21

(45)

Published

2018-01-25

(72)

Inventor

Fedorova Olga VasilevnaTitova Yuliya AlekseevnaRusinov Gennadij LeonidovichCharushin Valerij Nikolaevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Organicheskogo Sinteza Im. I.Ya. Postovskogo Uralskogo Otdeleniya Rossijskoj Akademii Nauk Uro Ran)

METHOD OF PRODUCING 6-ETHOXYCARBONYL-7- (THIEN-2-YL) -5-METHYL-4,7-DIHYDRO-1,2,4-TRIAZOLO [1,5-A]PYRIMIDINE THAT HAS HIGH TUBERCULOSTATIC ACTIVITY Russian patent published in 2018 - IPC C07D487/04

Abstract RU 2642420 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 6-ethoxycarbonyl-7-(thien-2-yl)-5-methyl-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine having tuberculostatic activity of the formula

which consists in interaction of 2-thiophenaldehyde, acetoacetic ester and 3-amino-1,2,4-triazole by heating in a solvent, where water is used as the solvent, with a molar ratio water: 2-thiophenaldehyde: acetoacetic ester: 3-amino-1,2,4-triazole is 55:1:1:1.

EFFECT: new simple technological method of obtaining a compound that does not require special equipment and acids and large volumes of organic solvents is developed.

3 ex

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RU 2 642 420 C1

Authors

Fedorova Olga Vasilevna

Titova Yuliya Alekseevna

Rusinov Gennadij Leonidovich

Charushin Valerij Nikolaevich

Dates

2018-01-25—Published

2017-04-21—Filed