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2 654 463

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IPC

C07D487/04(2006-01-01)

A61K31/519(2006-01-01)

A61P31/06(2006-01-01)

(21) (22)

Application

2017114061, 2017-04-21

(24)

Start date

2017-04-21

(22)

Actual filing date

2017-04-21

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Published

2018-05-18

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Inventor

Fedorova Olga VasilevnaTitova Yuliya AlekseevnaKravchenko Marionella AnatolevnaSkornyakov Sergej NikolaevichMedvinskij Igor DavydovichRusinov Gennadij LeonidovichCharushin Valerij Nikolaevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Organicheskogo Sinteza Im. I.Ya. Postovskogo Uralskogo Otdeleniya Rossijskoj Akademii Nauk Uro Ran)Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauchno-Issledovatelskij Institut Ftiziopulmonologii" Ministerstva Zdravookhraneniya Rossijskoj Federatsii Minzdrava Rossii)

ENANTIOMERS 6-ETHOXYCARBONYL-7-(THIEN-2-YL)-5-METHYL-4,7-DIGYDRO-1,2,4-TRIAZOLO[1,5-A]PYRIMIDINE AND 6-ETHOXYCARBONYL-7-PHENYL-5-METHYL-4,7-DIHYDRO-1,2,4-TRIAZOLO[1,5-A]PYRIMIDINE, WITH TUBERCULOSTATIC ACTIVITY Russian patent published in 2018 - IPC C07D487/04 A61K31/519 A61P31/06

Abstract RU 2654463 C1

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to enantiomers 6-ethoxycarbonyl-7-(thien-2-yl)-5-methyl-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine and 6-ethoxycarbonyl-7-phenyl-5-methyl-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine, possessing tuberculostatic activity. , where R = phenyl or thien-2-yl. As a result, (+)6-ethoxycarbonyl-7-(thien-2-yl)-5-methyl-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine, (-)6-ethoxycarbonyl-7-(thien-2-yl)-5-methyl-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine, (+)6-ethoxycarbonyl-7-phenyl-5-methyl-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine, (-)6-ethoxycarbonyl-7-phenyl-5-methyl-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine with high tuberculostatic activity are obtained.

EFFECT: high tuberculostatic activity.

1 cl, 1 tbl, 2 ex

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RU 2 654 463 C1

Authors

Fedorova Olga Vasilevna

Titova Yuliya Alekseevna

Kravchenko Marionella Anatolevna

Skornyakov Sergej Nikolaevich

Medvinskij Igor Davydovich

Rusinov Gennadij Leonidovich

Charushin Valerij Nikolaevich

Dates

2018-05-18—Published

2017-04-21—Filed