FIELD: biotechnology.
SUBSTANCE: set of oligonucleotides for the synthesis of a genetic construct intended for the correction of mitochondrial dysfunction caused by "basic deletion", a genetic construct and a method for genetic construct delivery to the human cells mitochondria, are provided.
EFFECT: more efficient integration of the genetic construct into the human cells mitochondria and reduced possibility of changes in the nuclear genome.
5 cl, 1 dwg, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR MOLECULAR DIAGNOSTICS OF MITOCHONDRIAL PATHOLOGIES BASED ON PYROSEQUENCING TECHNOLOGY | 2015 |
|
RU2633752C2 |
| METHOD OF HOMINAL MITOCHONDRIAL GENOME COPYING IN YARROWIA LIPOLYTICA YEAST CELLS | 2016 |
|
RU2660715C2 |
| GENETIC CONSTRUCT BASED ON CRISPR/Cas9 GENOME SYSTEM EDITING, CODING Cas9 NUCLEASE, SPECIFICALLY IMPORTED IN HUMAN CELLS MITOCHONDRIA | 2015 |
|
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| GENETIC CONSTRUCT FOR THE EXPRESSION OF RECOMBINANT DEAMINASES BASED ON APOBE1 FOR TARGETED MODIFICATION OF MITOCHONDRIAL DNA CYTOSINE BASES | 2022 |
|
RU2800362C1 |
| GENETIC CONSTRUCTS ENCODING NUCLEASES Cas9-BE4-Gam AND Cas9-ABE 7.10, WHICH ARE DIRECTED INTO MITOCHONDRIA OF HUMAN CELLS | 2018 |
|
RU2709739C1 |
| GENETIC CONSTRUCT PMITOASCPF1, CODING NUCLEASE ASCPF1 WITH DETERMINANT OF IMPLANTATION IN THE MITOCHONDRIA OF HUMAN CELLS | 2016 |
|
RU2662994C2 |
| METHOD OF DETERMINING DEGREE OF HETEROPLASMY MUTATIONS OF MITOCHONDRIAL GENOME | 2015 |
|
RU2600023C1 |
| NUCLEIC ACID FOR ALLOTOPIC EXPRESSION OF MT-ND4 GENE | 2023 |
|
RU2809065C1 |
| METHOD FOR DETERMINATION OF GENETIC PREDISPOSITION TO ATHEROSCLEROSIS, ISCHEMIC HEART DISEASE AND MYOCARDIAL INFARCTION | 2016 |
|
RU2641568C1 |
| MITOCHONDRIAL LOCALIZATION PEPTIDE, NUCLEIC ACID FOR ALLOTOPIC EXPRESSION OF MT-ND4 GENE CONTAINING ITS EXPRESSION VECTOR AND ITS USE | 2023 |
|
RU2817420C1 |
