FIELD: molecular biology.
SUBSTANCE: genetic construct for the expression of recombinant deominases based on APOBE1 and a method of its production are proposed. The pNtGGS1_TALE genetic construct is shown in FIG. 1 and provides for the expression of recombinant deominases based on APOBC1 for targeted modification of cytosine bases of mitochondrial DNA.
EFFECT: inventions can be used to edit point pathogenic mitochondrial DNA (mtDNA) mutations associated with various hereditary mitochondrial pathologies.
2 cl, 5 dwg, 3 tbl
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| GUIDED RNA TRANSCRIPTION REGULATION | 2014 |
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| TARGET RNA EDITING | 2015 |
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