FIELD: pharmacology.
SUBSTANCE: weight ratio of melphalan hydrochloride flufenamide (J1) and sucrose is 1:25 to 1:75. The invention also describes a method for preparation of a lyophilized preparation, compositions and kit containing a lyophilized pharmaceutical preparation and their use in treatment and/or prevention of cancer.
EFFECT: invention provides high solubility and a high dissolution rate of the lyophilized pharmaceutical preparation melphalan flufenamide in a physiologically acceptable solution and an increased stability of the said active ingredient.
39 cl, 4 tbl, 7 ex
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