PARTICLE AND PHARMACEUTICAL COMPOSITION CONTAINING INSOLUBLE CAMPTOTHECIN COMPOUND WITH DOUBLE CORE-SHELL STRUCTURE AND METHOD OF MANUFACTURE THEREOF Russian patent published in 2021 - IPC A61K9/107 A61K31/4745 A61K9/14 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention relates to a system of drug delivery with a double core-shell structure, particularly to a double system of nanodrug delivery with an inner core-shell structure containing a poorly soluble camptothecin compound and a water soluble camptothecin compound and with an amphiphilic polymer shell, and to a method of manufacture thereof. Particles with a double core-shell structure produced in accordance with the present invention form very stable particles and demonstrate homogenous distribution of particle prior to and after lyophilization.

EFFECT: particles in accordance with the present invention demonstrate excellent results compared with existing single layered micella in animal efficiency test, and surface-active agents leading to hypersensitivity are not used therein, so application of the particles in accordance with the present invention may result in a pharmaceutical composition or a base for a system of drug delivery which is safe for the human body.

12 cl, 6 dwg, 9 tbl, 12 ex