FIELD: pharmacology.
SUBSTANCE: invention relates to new analgesics based on 5-aryl-4-benzoyl-3-hydroxy-1-(4-guanidylsulfonylphenyl)-3-pyrrolin-2-ones. The analgesic activity of compounds I-III 
R=H (I), 4-Cl (II), 4-MeO (III), exceeds the activity of metamizole sodium and is comparable with the action of nimesulide by analgesic action.
EFFECT: increased activity of agents.
1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| USE OF 5-ARYL-4-AROYL-3-HYDROXY-1-CARBOXYMETHYL-3-PYRROLIN-2-ONES AS ANALGESICS | 2023 |
|
RU2816900C1 |
| 5-(4-HYDROXYPHENYL)-4-(4-METHOXYBENZOYL)-3-HYDROXY-1-(2,2-DIMETHOXYETHYL)-3-PYRROLIN-2-ONE, EXHIBITING ANALGESIC AND ANTIPYRETIC PROPERTIES | 2009 |
|
RU2429229C1 |
| USE OF 5-BENZOYL-4-HYDROXY-N-(4-IODOPHENYL)-6-(4-CHLOROPHENYL)-2-OXOHEXAHYDROPYRIMIDINE-4-CARBOXAMIDE AS AGENT WITH ANALGESIC ACTIVITY | 2023 |
|
RU2811249C1 |
| USE OF 4-[1-(4-METHYLPHENYL)AMINOETHYLIDENE]-5-PHENYL-1-CYANOMETHYLTETRAHYDROPYRROLE-2,3-DIONE AS AN ANALGESIC | 2023 |
|
RU2806330C1 |
| ETHYL 4-(5-BENZOYL-6-(4-(DIETHYLAMINO)PHENYL)-4-HYDROXY-2-THIOXOHEXAHYDROPYRIMIDIN-4-CARBOXAMINO)BENZOATE, EXHIBITING ANALGESIC AND ANTI-INFLAMMATORY ACTION | 2019 |
|
RU2717246C1 |
| USE OF 3,4-DIMETHYL-6-(3-NITROPHENYL)-2-OXO-N-PHENYL-1,2,3,6-TETRAHYDROPYRIMIDINE-5-CARBOXAMIDE AS AGENT WITH ANALGESIC ACTIVITY | 2022 |
|
RU2785688C1 |
| USE OF 4-(4-BROMOPHENYL)-6-METHYL-N-(2-CHLOROPHENYL)-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXAMIDE AS AN AGENT WITH ANALGESIC ACTIVITY | 2022 |
|
RU2793550C1 |
| APPLICATION OF 4-HYDROXY-4-METHYL-2-(3-NITROPHENYL)-6-(2-(2,4-DINITROPHENYL)HYDRAZONO)CYCLOHEXANE-1,3-DICARBOXAMIDE AS AN ANALGESIC AGENT | 2022 |
|
RU2786808C1 |
| SILVER SALTS OF 5,6-DIARYL-4-[4-(ACETYLAMINOSULPHONYL)PHENYL]-3,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-ONES EXHIBITING ANTIMICROBIAL ACTIVITY | 2019 |
|
RU2698328C1 |
| N-(2-THIAZOLYL)AMIDE OF 2-(2-OXO-3-INDOLINYLIDENE)HYDRAZINO-4-OXO-4-PHENYL-2-BUTENOIC ACID HAVING ANTIBACTERIAL AND ANALGESIC ACTIVITY | 2008 |
|
RU2401837C2 |
