FIELD: biotechnology.
SUBSTANCE: invention relates to fusion proteins for application as an immunogenic enhancing agent to enhance antigen-specific T-cell responses, and can be used in medicine. A fusion protein is produced recombinantly, which comprises: (a) a binding domain with an antigen-presenting cell (APC) or a binding domain with the CD91 receptor; (b) a protein transduction domain; (c) a pathogenic antigen. The binding domain with the antigen-presenting cell (APC) or the binding domain with the CD91 receptor is located at the N-terminus of the fusion protein, and the pathogenic antigen is located at the C-terminus of the protein transduction domain.
EFFECT: invention allows to obtain an enhanced antigen-specific T-cell response against a viral pathogen and cancer cell.
16 cl, 15 dwg, 2 tbl, 6 ex
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Authors
Dates
2017-09-15—Published
2013-12-03—Filed