FUSION PROTEINS FOR APPLICATION AS IMMUNOGENIC AMPLIFYING AGENTS TO INDUCE ANTIGEN-SPECIFIC T-CELL RESPONSE Russian patent published in 2017 - IPC C07K19/00 C07K14/05 C07K14/47 C07K14/705 A61K38/16 A61K39/385 A61P37/04

Abstract RU 2631002 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to fusion proteins for application as an immunogenic enhancing agent to enhance antigen-specific T-cell responses, and can be used in medicine. A fusion protein is produced recombinantly, which comprises: (a) a binding domain with an antigen-presenting cell (APC) or a binding domain with the CD91 receptor; (b) a protein transduction domain; (c) a pathogenic antigen. The binding domain with the antigen-presenting cell (APC) or the binding domain with the CD91 receptor is located at the N-terminus of the fusion protein, and the pathogenic antigen is located at the C-terminus of the protein transduction domain.

EFFECT: invention allows to obtain an enhanced antigen-specific T-cell response against a viral pathogen and cancer cell.

16 cl, 15 dwg, 2 tbl, 6 ex

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RU 2 631 002 C2

Authors

U Chia-Mao

Chan Siu-Kan

Dates

2017-09-15—Published

2013-12-03—Filed