SUBSTITUTED GUANIDINE COMPOUNDS Russian patent published in 2021 - IPC C07D401/04 C07D405/14 C07D491/107 A61K31/4427 A61P1/16 A61P13/12 

FIELD: medicine.

SUBSTANCE: present invention relates to a compound of the general formula (I) or its pharmaceutically acceptable salt:

,

where X is CR¹R², a carbonyl group, or a group of the formula (Ia):

; R¹ and R², independently of each other, are a hydrogen atom, a halogen atom, a hydroxy group, a substituted hydroxy group, an optionally substituted C₁-C₆alkyl group, or an optionally substituted C₁-C₆alkoxy group, where the term “substituted” refers to the substitution with at least one substituent selected from a group consisting of a deuterium atom, a halogen atom, a hydroxy group and C₁-C₆alkoxy group; p and q, independently of each other, are integers from 0 to 3, provided that the sum of p and q is 2 or more. A pharmaceutical composition with inhibitory activity against VAP-1, the use of a compound of the general formula (I) to obtain a drug, a method for treating a disease that can be prevented, relieved and/or treated by inhibiting VAP-1 are also proposed.

EFFECT: obtaining new compounds that exhibit inhibitory activity against vascular adhesion protein-1 (VAP-1).

20 cl, 4 tbl, 73 ex