FIELD: organic chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, namely to a method for producing derivatives of 6-aryl-5-(3-oxo-4-phenyl-3,4-dihydroquinoxalin-2-yl)-2,3-dihydro-4H-1,3-oxazin-4-one(3) (Ar=Ph, R+R=-СН2СН2ОСН2СН2- (a), Ar=С6Н4ОМе-4, R+R=-СН2СН2ОСН2СН2- (b), Ar=Ph, R=Me (c)). The method is carried out by heating a mixture of 3-aroyl-5-phenylpyrrolo[1,2-a]quinoxaline-1,2,4(5H)-triones (1) with cyanamides (2) to 230-250°C. The process is carried out without the use of a solvent.
EFFECT: method for the synthesis of derivatives of 6-aryl-5-(3-oxo-4-phenyl-3,4-dihydroquinoxalin-2-yl)-2,3-dihydro-4H-1,3-oxazin-4-one has been developed (3) that can be used in pharmacology.
1 cl, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING 5-(3-OXO-3,4-DIHYDROQUINOXALIN-2-YL)-2,3-DIHYDRO-4H-1,3-OXAZIN-4-ONES | 2019 |
|
RU2707194C1 |
| 3-(2-ARYL-2,4-DIHYDROXY-1(2-HYDROXYETHYL)-5-OXO-2,5-DIHYDRO-1H-PYRROL-3-YL)QUINOXALINE-2(1H)-ONES HAVING ANALGESIC ACTIVITY AND A METHOD FOR PRODUCTION THEREOF | 2019 |
|
RU2707196C1 |
| 3A-(4-R-PHENYL)-2-HYDROXY-3-(3-OXO-3,4-DIHYDROQUINOXALIN-2-YL)BENZO[D]PYRROLO[2,1-B]THIAZOL-1(3AH)-ON | 2022 |
|
RU2783288C1 |
| 2-ARYL-2,4-DIHYDROXY-2,5-DIHYDRO-3-HETERYL-5-OXO-1H-PYRROL-1-YL-4-METHYL BENZENESULPHANOLAMIDES WITH ANALGESIC ACTIVITY | 2015 |
|
RU2626650C2 |
| PYRIDINE DERIVATIVES OF BIS(3,4-DIHYDROQUINOXALIN-2(1N)-ONE) AND BIS(3,4-DIHYDRO-2N-BENZO[B][1,4]OXAZIN-2-ONE), HAVING ANALGESIC ACTIVITY | 2018 |
|
RU2688217C1 |
| (Z)-4-ARYL-N-[2-(2-HYDROXYMETHYL)PHENYL]-2,4-DIOXO-3-[3-OXO-3,4-DIHYDROQUINOXALINE-2(1N)-YLIDENE]BUTANAMIDES, HAVING ANALGESIC ACTIVITY | 2019 |
|
RU2722178C1 |
| 2-AMINO-6-HYDROXY-7-(3-OXO DIHYDROQUINOXALINE-2-yl)-7a-PHENYL-PYRROLO[2,1-b][1,3,4]THIADIAZOLE-5(7aH)-ONS WITH ANTI-INFLAMMATORY ACTIVITY, AND THE METHOD FOR THEIR PREPARATION | 2021 |
|
RU2778090C1 |
| (Z)-ETHYL2-(4-(4-CHLOROPHENYL)-2,4-DIOXO-3-(3-OXO-3,4-DIHYDROQUINOXALIN-2(1H)-YLIDENE)BUTANAMIDO)-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE HAVING ANTIDIABETIC ACTIVITY, AND METHOD FOR PRODUCTION THEREOF | 2015 |
|
RU2606230C1 |
| 4 - ((2-ARYL-2,4-DIHYDROXY-5-OXO-3-(3-OXO-3,4-DIHYDROQUINOXALIN-2-YL)-2,5-DIHYDRO-1N-PYRROL-1-YL)AMINO)BENZOIC ACIDS HAVING ANALGESIC ACTIVITY | 2019 |
|
RU2731215C1 |
| METHOD OF OBTAINING 1,2-DIHYDRO-3H-PYRIMIDO[1,6-A]QUINOXALINE-3,5(6H)-DIONES | 2018 |
|
RU2676682C1 |
