FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing compounds of class 5-(3-oxo-3,4-dihydroquinoxalin-2-yl)-2,3-dihydro-4H-1,3-oxazin-4-one of formula II, having antihypoxic activity, and also can be used as initial products for synthesis of new heterocyclic systems and in pharmacology. Method comprises heating to 180–190 °C a finely divided mixture of 3-aroyl-5-phenylpyrrolo[1,2-a]quinoxaline-1,2,4(5H)-triones with dicyclohexylcarbodiimide until termination of CO emission and subsequent extraction of the end product.
EFFECT: technical result of the invention is to develop a simple method of synthesis of 5- (3-oxo-3,4-dihydroquinoxalin-2-yl) -2,3-dihydro-4H-1,3-oxazin-4-ones without using a solvent for carrying out the reaction.
1 cl, 2 tbl, 3 ex
| Title |
Year |
Author |
Number |
| METHOD FOR PREPARING 6-ARYL-5-(3-OXO-4-PHENYL-3,4-DIHYDROQUINOXALIN-2-YL)-2,3-DIHYDRO-4H-1,3-OXAZIN-4-ONES |
2021 |
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|
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2018 |
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2019 |
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|
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2015 |
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|
RU2581268C1 |
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2021 |
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|
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2015 |
- Maslivets Andrej Nikolaevich
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|
RU2581271C1 |
| 3A-(4-R-PHENYL)-2-HYDROXY-3-(3-OXO-3,4-DIHYDROQUINOXALIN-2-YL)BENZO[D]PYRROLO[2,1-B]THIAZOL-1(3AH)-ON |
2022 |
- Mashevskaia Irina Vladimirovna
- Lukmanova Dzhamilia Nailevna
- Dmitriev Maksim Viktorovich
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|
RU2783288C1 |
| 16-ALKOXY-14-ARYL-15-OXA-3,10-DIAZATETRACYCLO [8.7.0.0.0]HEPTADECA-4,6,8,13-TETRAENE-2,11,12-TRIONES AND METHOD FOR PRODUCING THEM |
2013 |
- Stepanova Ekaterina Evgen'Evna
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- Makhmudov Ramiz Ragibovich
|
RU2556999C2 |
| 9-ARYL-6,8,20-TRIOXA-13-AZAPENTACYCLO[11,8,0,01,10,02,7014,19]HENEICOSA-9,14,16,18-TETRAENE-11,12,21-TRIONES AND METHOD FOR PRODUCTION THEREOF |
2013 |
- Stepanova Ekaterina Evgen'Evna
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|
RU2556998C2 |
