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2 649 398

(13)

(51)

IPC

C07D333/36(2006-01-01)

C07D409/04(2006-01-01)

C07D409/12(2006-01-01)

C07D409/14(2006-01-01)

C07D417/12(2006-01-01)

A61K31/381(2006-01-01)

A61K31/427(2006-01-01)

A61K31/4436(2006-01-01)

A61P1/16(2006-01-01)

A61P11/00(2006-01-01)

A61P13/12(2006-01-01)

(21) (22)

Application

2015131139, 2013-12-27

(24)

Start date

2013-12-27

(22)

Actual filing date

2013-12-27

(45)

Published

2018-04-03

(72)

Inventor

Ivase NoriakiNisida KhirosiOkudo MakotoIto MasaakiKono SigeyukiMatoyama MasaakiUsiyama SigeruOkanari EjdziMatsunaga KhirofumiNisikava KendziKimura Tomio

(73)

Holder

Ube Indastriz, Ltd.

HALOGEN SUBSTITUTED HETEROCYCLIC COMPOUND Russian patent published in 2018 - IPC C07D333/36 C07D409/04 C07D409/12 C07D409/14 C07D417/12 A61K31/381 A61K31/427 A61K31/4436 A61P1/16 A61P11/00 A61P13/12

Abstract RU 2649398 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound represented by the general formula (I)

(I)

wherein A represents, a phenyl ring, a thiophene ring, or an isothiazole ring; R¹ is the same or different, and represents a halogen atom, or a C₁-C₃alkyl group; R² represents a hydrogen atom, or a C₁-C₆ alkyl group; p represents an integer of 0 to 5; V represents CR³ wherein R³ represents a hydrogen atom, amino group, nitro group, or a C₁-C₃ alkoxy group, or V represents a nitrogen atom; and X represents a halogen atom. Invention also relates to individual compounds, a receptor antagonist for LPA, a pharmaceutical composition.

EFFECT: new compounds having antagonistic activity in relation to the receptor for lysophosphatidic acid (LPA) have been obtained.

28 cl, 217 ex, 3 tbl

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RU 2 649 398 C2

Authors

Ivase Noriaki

Nisida Khirosi

Okudo Makoto

Ito Masaaki

Kono Sigeyuki

Matoyama Masaaki

Usiyama Sigeru

Okanari Ejdzi

Matsunaga Khirofumi

Nisikava Kendzi

Kimura Tomio

Dates

2018-04-03—Published

2013-12-27—Filed