HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND Russian patent published in 2021 - IPC C07D333/36 C07D409/04 C07D409/12 C07D409/14 C07D417/12 A61K31/381 A61K31/427 A61K31/4436 A61P1/16 

Abstract RU 2756506 C2

FIELD: medicine; pharmaceutics.

SUBSTANCE: group of inventions relates to the field of medicine and pharmaceutics, more specifically to the use of a compound represented by the general formula (I), in which A is phenyl ring, thiophene ring or isothiazole ring; R1 are the same or different, and are a halogen atom or C1-C3 alkyl group; R2 is a hydrogen atom or C1-C6 alkyl group; p is an integer from 0 to 5; V is CR3, in which R3 is a hydrogen atom, an amino group, a nitro group, or C1-C3 alkoxy group, or V is a nitrogen atom; X is an atom of halogen or its pharmacologically acceptable salt for the treatment or prevention of non-alcoholic steatohepatitis (NASH) caused by a receptor of lysophosphatidic acid (LPA). A method for the treatment or prevention of non-alcoholic steatohepatitis (NASH) caused by the receptor of lysophosphatidic acid is also described, including the injection of the compound represented by the general formula (I).

EFFECT: technical result is providing the use of α-halogen-substituted thiophene with strong antagonistic activity relatively to the receptor to LPA for the treatment or prevention of non-alcoholic steatohepatitis.

14 cl, 3 tbl, 154 ex

Similar patents RU2756506C2

Title Year Author Number
HALOGEN SUBSTITUTED HETEROCYCLIC COMPOUND 2013
  • Ivase Noriaki
  • Nisida Khirosi
  • Okudo Makoto
  • Ito Masaaki
  • Kono Sigeyuki
  • Matoyama Masaaki
  • Usiyama Sigeru
  • Okanari Ejdzi
  • Matsunaga Khirofumi
  • Nisikava Kendzi
  • Kimura Tomio
RU2649398C2
HALOGEN SUBSTITUTED HETEROCYCLIC COMPOUND SALT 2015
  • Iwase, Noriaki
  • Nishida, Hiroshi
  • Okudo, Makoto
  • Ito, Masaaki
  • Kono, Shigeyuki
  • Matoyama, Masaaki
  • Ushiyama, Shigeru
  • Okanari, Eiji
  • Matsunaga, Hirofumi
  • Nishikawa, Kenji
  • Kimura, Tomio
RU2689315C2
HETEROCYCLIC DERIVATIVES AND USE THEREOF 2014
  • Park Chan Khee
  • Li Sang Khvi
  • Im Dzunkhvan
  • Li Soon Ok
  • Kim Khoe Moon
  • Moon Sung Khyun
  • Kim Seungkhi
  • Kim Dzongmin
  • Ko Kvang Seok
  • Choi Bu Yang
  • Kim Byungkho
RU2681849C2
ALKALOID ESTER AND CARBAMATE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF 2012
RU2611627C2
PROLYL HYDROXYLASE INHIBITORS AND APPLICATION METHODS THEREOF 2007
  • Kavamoto Richard Masaru
  • Bojer Anzhelik San
  • Grejz Kennet Donal'D
  • Evdokimov Artem G.
  • Vu Shehndeh
  • Varshakun Namal Chitranga
RU2429226C9
THIAZOLIDINEDIONE SALTS WITH REDUCED AFFINITY TO PPAR FOR TREATMENT OF METABOLIC DISORDERS 2010
  • Kolka Dzherard R.
  • Tanis Stiven P.
  • Larsen Skott D.
RU2564661C2
NOVEL POLYCYCLIC COMPOUNDS 2006
  • Aidt Ehval'D
  • Kranikh Remo
  • Buzemann Anke
RU2434006C2
TRIAZOLOPYRIDINES AS PHOSPHODIESTERASE INHIBITORS FOR TREATING SKIN DISEASES 2009
  • Nil'Sen Simon Fel'Dbek
  • Vifian Tomas
  • Khorneman Anne Marija
  • Lau Jesper Fergemann
RU2544011C2
ARYLALKYL ESTERS OF 4-AMINO-6-(SUBSTITUTED PHENYL)PICOLINATES AND 6-AMINO-2-(SUBSTITUTED PHENYL)-4-PYRIMIDINE CARBOXYLATES AND USE THEREOF AS HERBICIDES 2012
  • Jerks Karla N.
  • Lou Kristian T.
  • Ehkkel'Bardzher Dzhozef D.
  • Ehpp Dzheffri B.
  • Gjuntenspberger Katerine A.
  • Siddall Tomas L.
  • Shmittser Pol R.
RU2566760C2
CARBOSTYRIL COMPOUND 2005
  • Kuroda Takesi
  • Jamauti Takakhito
  • Sinokhara Tomoiti
  • Osima Kunio
  • Kitadzima Tikharu
  • Nagao Khitosi
  • Fukusima Tae
  • Tomojasu Takakhiro
  • Isijama Khironobu
  • Okhta Kazukhide
  • Takano Masaaki
  • Sumida Takumi
RU2430920C2

RU 2 756 506 C2

Authors

Iwase, Noriaki

Nishida, Hiroshi

Okudo, Makoto

Ito, Masaaki

Kono, Shigeyuki

Matoyama, Masaaki

Ushiyama, Shigeru

Okanari, Eiji

Matsunaga, Hirofumi

Nishikawa, Kenji

Kimura, Tomio

Dates

2021-10-01Published

2013-12-27Filed