PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF GALLBLADDER CANCER Russian patent published in 2018 - IPC A61K39/395 A61P35/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions relates to medicine and concerns a pharmaceutical composition having antitumor activity against gallbladder cancer cells, which contains, as an active ingredient, an antibody or a fragment thereof that has an immunological reactivity with respect to the CAPRIN-1 protein, comprising an amino acid sequence set forth in any of even sequence numbers from SEQ ID NOs: from 2 to 30, or an amino acid sequence having a sequence identity of 80 % or more to the amino acid sequence or a CAPRIN-1 protein fragment, comprising at least seven consecutive amino acid residues of the amino acid sequence of the protein. Group of inventions also relates to a combined pharmaceutical agent having antitumor activity against gallbladder cancer cells, which comprises a combination of said pharmaceutical composition and a pharmaceutical composition containing an antitumor agent. Group of inventions also relates to the use of said pharmaceutical composition or combined pharmaceutical agent for inhibiting the growth of gallbladder cancer cells.

EFFECT: group of inventions provides antitumor activity against gallbladder cancer cells.

9 cl, 16 ex