FIELD: pharmacology.
SUBSTANCE: invention relates to an antibody or a binding fragment thereof that specifically binds to the CAPRIN-1 protein and has immunological reactivity to the partial CAPRIN-1 polypeptide. Also a conjugate, as well as a pharmaceutical composition and a pharmaceutical combination for treatment or prevention of a malignant tumour expressing CAPRIN-1 are disclosed. The invention also relates to a method for treatment or prevention of a cancer expressing CAPRIN-1 using the above antibody or a fragment thereof, a conjugate, a composition or a combination.
EFFECT: invention enables efficient treatment or prevention of cancer expressing CAPRIN-1.
19 cl, 12 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PHARMACEUTICAL COMPOSITION FOR PANCREATIC CANCER TREATMENT AND/OR PREVENTION | 2012 |
|
RU2630638C2 |
| PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING MALIGNANT GROWTH | 2012 |
|
RU2595400C2 |
| PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING MALIGNANT GROWTH | 2012 |
|
RU2610428C2 |
| PHARMACEUTICAL COMPOSITION FOR CANCER TREATMENT AND/OR PREVENTION | 2012 |
|
RU2611197C2 |
| PHARMACEUTICAL COMPOSITION FOR CANCER TREATMENT AND PREVENTION | 2012 |
|
RU2624049C2 |
| METHOD FOR CANCER DETECTION | 2013 |
|
RU2646464C2 |
| PHARMACEUTICAL COMPOSITION FOR TREATING AND PREVENTING MALIGNANT GROWTHS | 2009 |
|
RU2498819C2 |
| METHOD FOR CANCER DETECTION | 2013 |
|
RU2646466C2 |
| PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF CANCER | 2011 |
|
RU2603742C2 |
| PHARMACEUTICAL COMPOSITION FOR LIVER CANCER TREATMENT AND/OR PREVENTION | 2013 |
|
RU2640245C2 |
