PHARMACEUTICAL COMPOSITION FOR TREATING AND PREVENTING MALIGNANT GROWTHS Russian patent published in 2013 - IPC A61K39/395 C07K16/18 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention discloses an antibody (versions) possessing immunologic responsiveness to incomplete polypeptide CAPRIN-1 (the amino acid sequences are presented in the description), and a pharmaceutical composition (versions) for treating and/or preventing a malignant growth, particularly breast cancer, cerebral tumour, leukaemia, lymphoma, lung cancer, or colon cancer. As an active ingredient, the composition contains an antibody or a fragment thereof possessing immunologic responsiveness to the protein CAPRIN-1 or a fragment thereof containing 7 more or more sequential amino acids. The antibody can be monoclonal, polyclonal, human, humanised, chimeric, single-chain or bispecific antibody. What is disclosed is a method of treating and/or preventing a malignant growth with using the antibody or the immunologically active fragment thereof.

EFFECT: antibodies according to the invention show the pronounced antitumour effect particularled ensured by their ability to damage the tumour cells expressing CAPRIN-1, and are attractive for treating the oncological diseases.

22 cl, 10 dwg, 7 ex