METHOD FOR PREDICTING DEVELOPMENT OF BRONCHOPULMOUS HEAVY DISPLOSITION IN UNEMPLOYED CHILDREN WITH AN EXTREMELY LOW BODY MASS IN THE NEONATAL PERIOD Russian patent published in 2018 - IPC G01N33/53 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely, pulmonology and neonatology, and can be used for early prediction of bronchopulmonary dysplasia (BPD) of a severe degree in preterm infants born with extremely low body weight (ELBW). Method consists in determining the relative percentage of CD14⁺HLA-DR⁺-monocytes and CD4⁺CD25⁺-lymphocytes, the presence of severe anemia, requiring blood transfusion in the neonatal period, in the umbilical blood of children by the flow cytofluorometry method. Prognostic index is calculated (PI): PI = 0.074×X1+6.72×X2+3.27×X3-5.31, where: X1 – relative percentage of CD14⁺HLA-DR⁺-monocytes of blood, %; X2 is the absolute number of CD4⁺CD25⁺-lymphocytes, 10⁹/l; X3 – presence/absence of severe anemia in the neonatal period, requiring a blood transfusion (1/0); 5.31 – constanta. At values PI < 0, a high risk of developing bronchopulmonary dysplasia of a severe degree is predicted, and at PI > 0, a conclusion about the low risk of development of this pathological condition in premature infants with ELBW is made.

EFFECT: method improves the prognosis efficiency of the development of bronchopulmonary dysplasia of severe degree in children with extremely low body weight, which makes possible to correct the tactics of conducting premature babies at the survival stages.

1 cl, 4 ex