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2 650 780

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IPC

C07K14/435(2006-01-01)

A61K38/17(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2016147736, 2016-12-06

(24)

Start date

2016-12-06

(22)

Actual filing date

2016-12-06

(45)

Published

2018-04-17

(72)

Inventor

Vasilevskij Aleksandr AleksandrovichOparin Petr BorisovichKorolkova Yuliya VladimirovnaMosharova Irina VladimirovnaSavchenko Ganna AnatolievnaBojchuk Yaroslav AnatolievichKryshtal Oleg Aleksandrovich

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennostyu Budushchego"

PEPTIDE MODULATOR OF PURINERGIC RECEPTORS Russian patent published in 2018 - IPC C07K14/435 A61K38/17 A61P29/00

Abstract RU 2650780 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to biologically active peptides modulating purinergic signaling, and can be used to develop new drugs on their basis, for example, analgesics, to study the mechanisms of pain, to detect and test new modulators of the P2X3 receptor. Peptide having the following amino acid sequence is proposed: Gly¹-Tyr²-Cys³-Ala⁴-Thr⁵-Lys⁶-Gly⁷-Ile⁸-Lys⁹-Cys¹⁰-Asn¹¹-Asp¹²-Ile¹³-His¹⁴-Cys¹⁵-Cys¹⁶-Ser¹⁷-Gly¹⁸-Leu¹⁹-Lys²⁰-Cys²¹-Asp²²-Ser²³-Lys²⁴-Arg²⁵-Lys²⁶-Val²⁷-Cys²⁸-Val²⁹-Lys³⁰-Gly³¹ - SEQ ID NO: 1.

EFFECT: invention makes it possible to obtain an effective antagonist of Purinergic P2X3 receptors.

2 cl, 2 dwg

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RU 2 650 780 C1

Authors

Vasilevskij Aleksandr Aleksandrovich

Oparin Petr Borisovich

Korolkova Yuliya Vladimirovna

Mosharova Irina Vladimirovna

Savchenko Ganna Anatolievna

Bojchuk Yaroslav Anatolievich

Kryshtal Oleg Aleksandrovich

Dates

2018-04-17—Published

2016-12-06—Filed