FIELD: veterinary.
SUBSTANCE: inventions relate to veterinary virology and biotechnology and relate to the vaccine and the way it is prepared. Method of manufacturing vaccine includes culturing the viral antigen in a suspension culture of VNK-21 cells, inactivation, purification of the viral suspension from ballast admixtures, concentration of the antigen of the foot-and-mouth disease virus obtained, and coupling with the adjuvant. As adjuvant oil adjuvant Montanide ISA-61 VG (Seppic, France) is used, which is sterilized by means of filters. Virus-containing suspension is purified by filtration, the antigenic material is concentrated by flowing ultrafiltration.
EFFECT: inventions allow to obtain more effective, safe and economically feasible anti-murrain drugs and provide an increase in the intensity and duration of the immunogenic activity of the foot-and-mouth disease vaccine and a reduction in its reactogenicity.
12 cl, 10 tbl, 12 ex
| Title | Year | Author | Number |
|---|---|---|---|
| INACTIVATED EMULSION VACCINE AGAINST FOOT-AND-MOUTH DISEASE TYPE A | 2017 |
|
RU2665850C1 |
| INACTIVATED EMULSION VACCINE FOR O-TYPE APHTHOUS FEVER | 2017 |
|
RU2682876C1 |
| INACTIVATED EMULSION VACCINE AGAINST FOOT-AND-MOUTH DISEASE TYPE O | 2017 |
|
RU2665849C1 |
| VACCINE FOR EARLY PROTECTION AGAINST FOOT-AND-MOUTH DISEASE OF TYPE O INACTIVATED EMULSION | 2019 |
|
RU2699671C1 |
| INACTIVATED EMULSION VACCINE AGAINST FOOT-AND-MOUTH DISEASE TYPES A, O, ASIA-1 | 2015 |
|
RU2593718C1 |
| INACTIVATED EMULSION VACCINE AGAINST FOOT-AND-MOUTH DISEASE OF TYPE A | 2005 |
|
RU2294759C2 |
| VACCINE FOR EARLY PROTECTION AGAINST FOOT-AND-MOUTH DISEASE OF TYPE ASIA-1 INACTIVATED EMULSION | 2020 |
|
RU2741639C1 |
| CULTURAL INACTIVATED EMULSION VACCINE AGAINST O/EA-3 GENOTYPE FOOT-AND-MOUTH DISEASE OF O N2241/ETHIOPIA/2011 STRAIN | 2023 |
|
RU2816264C1 |
| CULTURAL INACTIVATED EMULSION VACCINE AGAINST FOOT AND MOUTH DISEASE FROM O NO. 2620/ORENBURGSKY/2021 STRAIN OF O/ME-SA/IND-2001E GENOTYPE | 2023 |
|
RU2815537C1 |
| CULTURAL INACTIVATED EMULSION VACCINE AGAINST FOOT-AND-MOUTH DISEASE SEROTYPE O FROM STRAIN "O/ARRIAH/MYA-98" | 2023 |
|
RU2816944C1 |
