SYSTEM (VARIANTS) AND METHOD OF DETECTING ANALYTE PRESENCE IN LIQUID SAMPLE Russian patent published in 2018 - IPC G01N24/00 G01N33/553 C12Q1/68 G01R33/12 C12M1/34 

FIELD: measurement technology.

SUBSTANCE: present inventions relate to a method for detecting the presence of an analyte in a liquid sample, a method for detecting the presence of a pathogen in a whole blood sample, a method for detecting the presence of a virus in a whole blood sample, a method for detecting the presence of a target nucleic acid in a whole blood sample, a method of detecting the presence of organisms, related to Candida species in a liquid sample, systems for detecting one or more nucleic acid analytes in a liquid sample, and a replaceable cartridge for the placement of reagents for analysis and consumables in the specified system. Present inventions are characterised in that magnetic particles are used in their implementation, having an average diameter in the range from 700 nm to 950 nm, the value of relaxivity T₂ per particle of 1 x 10⁹ to 1 x 10¹² mmol^-1s^-1, and having binding residues on their surface, said binding residues acting, changing the aggregation of magnetic particles in the presence of the analyte.

EFFECT: inventions provide multiplex detection of multiple types of different molecules and can be used in clinical practice.

31 cl, 29 dwg, 19 ex, 13 tbl